The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Update to provide additional information to healthcare providers, public health departments, and the public about the ongoing risk of dengue virus (DENV) infections and updates to testing recommendations in the United States. Dengue activity remains high in some parts of the United States and globally, with many countries reporting higher-than-usual number of dengue cases in 2024 and 2025. Healthcare providers, public health departments, and the public are urged to continue to take steps to prevent, detect, diagnose, and respond to dengue as described in the June 2024 HAN Health Advisory (CDCHAN-00511) on dengue in the United States. Updates include:
- Dengue virus transmission remains high in the Americas region, including in the U.S. territories of Puerto Rico and the U.S. Virgin Islands. Spring and summer travel coincide with the peak season for dengue in many countries, increasing the risk of both travel-associated and locally acquired cases in the United States.
- Use the CDC DENV-1-4 real time reverse transcriptase polymerase chain reaction (RT-PCR) assay when dengue is the most likely diagnosis, linked here: https://www.cdc.gov/dengue/hcp/diagnosis-testing/cdc-denv-1-4-real-time-rt-pcr-multiplex-assay.html
- New resources are available for public health professionals including a job aid (https://www.cdc.gov/dengue/php/resources/medical_records_review.html) for reviewing medical records and guidance (https://www.cdc.gov/dengue/media/pdfs/2024/08/response_to_dengue.pdf) for investigating and responding to dengue cases in non-endemic areas of the United States.
For information about Dengue activity in the United States, please click here: https://www.cdc.gov/dengue/outbreaks/2024/index.html
For global information about Dengue in 2024 and 2025, please click here: https://wwwnc.cdc.gov/travel/notices/level1/dengue-global
For the full report, please click here: https://www.cdc.gov/han/2025/han00523.html
